RESUMO
Introducción: La infección por VIH continúa siendo un problema de salud pública a nivel mundial. Las restricciones tomadas durante la pandemia por COVID-19 podrían afectar el alcance de las metas 95-95-95 propuestas por ONUSIDA. El objetivo de este trabajo fue determinar el impacto de la pandemia por COVID-19 en la realización de pruebas rápidas de VIH en un hospital general de agudos.Métodos: Análisis retrospectivo de los datos de pacientes mayores de 16 años, de ambos sexos, que se realizaron una prueba rápida de VIH durante la pandemia por COVID-19 vs. el período previo.Resultados: De 611 tests, 473 (77,4%) corresponden al período prepandémico y 138 (22,6%) al pandémico. La mediana de edad (rango intercuartílico) fue 32 años (24-40); sexo masculino 386 (63,2%), sin diferencias significativas. Durante el período prepandémico los motivos de testeo fueron control de salud 47,6% (n=225) y situaciones de riesgo/síntomas 52,4% (n=248), mientras que en el período pandémico fueron control de salud 27,5% (n=38) y situaciones de riesgo/síntomas 72,5% (n=100) respectivamente, p=0.0001. Tests positivos: 5,7% (n=27) vs. 8,7% (n=12), p=0.28. Las medianas de recuento de linfocitos T CD4+ y carga viral fueron: 327 cel/uL (135-718) y 66300 copias/mL (5260-192000), sin diferencias significativas.Conclusiones: La cantidad de testeos realizados durante la pandemia corresponde a un tercio de los realizados durante el período previo, con un descenso en aquellos motivados por controles de salud, evidenciando el impacto de la pandemia en el diagnóstico de VIH
INTRODUCTION: HIV infection remains as a public health worldwide problem. The restrictions taken during the COVID-19 pandemic could have affected the scope of the 95-95-95 goals proposed by UNAIDS. The aim of this work is to determine the impact of the COVID-19 pandemic on the performance of rapid HIV tests in an Acute General Hospital.METHODS: Retrospective analysis of data from patients over 16 years old, of both sexes, who underwent a rapid HIV test during the COVID-19 pandemic vs. the previous period.RESULTS: Of 611 tests, 473 (77.4%) correspond to the pre-pandemic period and 138 (22.6%) to the pandemic. The median age (interquartile range) was 32 years old (24-40); male sex 386 (63.2%), without significant differences. During the pre-pandemic vs pandemic period, the reasons for testing were: health control 47.6% (n=225) and risk situations/symptoms 52.4% (n=248), vs 27.5% (n= 38) and 72.5% (n=100) respectively, p=0.0001. Positive tests: 5.7% (n=27) vs 8.7% (n=12), p=0.28. The median CD4+ T lymphocyte count and viral load were: 327 cells/uL (135-718) and 66,300 copies/mL (5,260-192,000), with no significant differences.CONCLUSIONS: The number of tests carried out during the pandemic equals to a third of those performed during the previous period, with a decrease in those motivated by health controls; evidencing the impact of the pandemic on the diagnosis of HIV
Assuntos
Humanos , Adulto , Pessoa de Meia-Idade , Idoso , Estudos Retrospectivos , Diagnóstico Precoce , Pandemias/prevenção & controle , Teste de HIV , COVID-19/prevenção & controleRESUMO
Background: Vaccination for COVID-19 in healthcare workers (HCW) is essential to protect one of the populations most exposed to this disease. However, data on the humoral response rate to the vaccine and the factors associated with it in this population are limited. Therefore, we aimed to evaluate the antibody response against SARS-CoV-2 in HCWs with complete Sputnik V vaccine scheme and factors associated with an increased antibody response. Material and methods: Prospective study to evaluate the anti-SARS-CoV-2 humoral response in HCWs vaccinated with two doses of the Sputnik V vaccine (April-July 2021). The assessment of anti-Spike IgG antibodies in plasma was performed using the COVIDAR IgG enzyme-linked immunosorbent assay. A logistic regression was performed to identify independent factors associated with a positive IgG serology test and an elevated antibody response. Results: A total of 630 HCWs were enrolled. Median age (IQR): 47 years (35-56). Female sex: 462 (73.33%). Previous COVID-19: 158 (25%). The median interval time between vaccine doses was 3 (3-4) weeks. Positive serology was observed in 607 (96.35%) HCWs. In the multivariate analysis, a history of systemic reactogenicity was identified as an independent variable associated with a positive serology; and history of systemic reactogenicity, COVID-19, interval between doses ≥ 4 weeks and time to serology < 14 weeks were associated with an elevated antibody response. Conclusions: This study provides data on the humoral response to the Sputnik V vaccine in a real-life setting. These initial data can contribute to the development of future immunization strategies in HCWs.
